New York Timesbestselling author Charles Graeber tells the astonishing story of the group of scientists working on a code that can enable the human immune system to fight -- and perhaps even cure -- cancer. For decades, scientists have puzzled over one of medicine's greatest mysteries: why doesn't our immune system fight cancer the way it does other diseases? The answer is a series of tricks that cancer has developed to turn off normal immune responses -- tricks that scientists have only recently discovered, and now are learning to defeat. We are in the midst of a revolution in our understanding of cancer and how to beat it. Groundbreaking, riveting, and expertly told, The Breakthroughis the story of the game-changing and Nobel Prize-winning scientific discoveries that unleash our natural ability to recognise and defeat cancer, as told through the experiences of the patients, physicians, and immunotherapy researchers who are on the front lines. This is the incredible true story of the race to find a cure, and the definitive account of a historic moment in medical science.