How do you begin to understand the concept of nothing? Where does it begin and where does it end? From the zeros of the mathematician to the void of the philosophers, from Shakespeare to the empty set, from the ether to the quantum vacuum, from being and nothingness to creatio ex nihilo, there is much ado about nothing at the heart of things. Recent exciting discoveries in astronomy are shown to shed new light on the nature of the vacuum and its dramatic effect upon the explanation of the Universe. This remarkable book ranges over every nook and cranny of nothingness to reveal how the human mind has had to make something of nothing in every field of human enquiry.